Our Scientific Publications
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Nature Genetics · November 20, 2024
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Nature Biotechnology · November 21, 2024
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling.
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bioRxiv · November 14, 2024 · Preprint
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord.
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Genetics in Medicine · November 12, 2024
Upregulation vs. loss of function of NTRK2 in 44 affected individuals leads to two distinct neurodevelopmental disorders.
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Alzheimer's & Dementia · November 13, 2024
Large-scale deep proteomic analysis in Alzheimer’s disease brain regions across race and ethnicity.
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Cell · November 7, 2024
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells.
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Nature · October 30, 2024
RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.
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European Journal of Radiology · October 15, 2024
[18F]-Fluoroestradiol (FES) brain PET in the evaluation of patients with estrogen receptor positive breast cancer and known or suspected brain metastases.
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bioRxiv · October 17, 2024 · Preprint
An analysis of RNA quality metrics in human brain tissue.
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bioRxiv · October 16, 2024 · Preprint
A Reproducibility Focused Meta-Analysis Method for Single-Cell Transcriptomic Case-Control Studies Uncovers Robust Differentially Expressed Genes.
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bioRxiv · October 15, 2024 · Preprint
Efficient indexing and querying of annotations in a pangenome graph.
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bioRxiv · October 11, 2024 · Preprint
Targetable treatment resistance in thyroid cancer with clonal hematopoiesis.
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Nature · October 9, 2024
The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution.
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Nature Biotechnology · October 7, 2024
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap.
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American Journal of Human Genetics · October 3, 2024
Semi-supervised machine learning method for predicting homogeneous ancestry groups to assess Hardy-Weinberg equilibrium in diverse whole-genome sequencing studies.
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Genome Research · October 2, 2024
High-coverage nanopore sequencing of samples from the 1000 Genomes Project to build a comprehensive catalog of human genetic variation.
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Cell · October 2, 2024
Private information leakage from single-cell count matrices.
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bioRxiv · September 25, 2024 · Preprint
Complex genetic variation in nearly complete human genomes.
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Proceedings of the National Academy of Sciences · September 23, 2024
Nr2f1 enhancers have distinct functions in controlling Nr2f1 expression during cortical development.
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Nature Genetics · September 24, 2024
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution.
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bioRxiv · September 22, 2024 · Preprint
Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair for somatic benchmarks.