The recently published Simons Foundation Annual Report features the work of its Flatiron Institute with the New York Genome Center’s Center for Genomics of Neurodegenerative Disease (CGND) and other collaborators that applied novel technology to enable the study of the co-expression of different groups of genes throughout the diseased spinal cord. The study, which was published in Science, showed for the first time how the location and extent of gene expression changes as ALS progresses.
“We know now ‘neighborhood matters’ in ALS,” says Hemali Phatnani, PhD, Director, CGND, referring to how non-neuronal cells can affect neurons’ vulnerability.
