Wigler Lab

Dr. Wigler’s research is presently focused on the genomics of cancer and the genetics of autism and related disorders. Together with members of his laboratory they have demonstrated the feasibility of single cell sequencing for genomic analysis and expects this work will eventually improve the targeting of cancer treatments and lead to early and less invasive tests for cancer. His studies in human genetics led to the discovery of a vast unsuspected source of genetic variability known as copy number variation (CNV), and to the hypothesis that spontaneous mutation is a major contributor of autism.