Imieliński Lab

The Imieliński Lab applies cancer genome assembly and long molecule sequencing to study the chromosomal structure of DNA in cancer. The lab develops new algorithms and genomic assays, and applies them to clinical samples to gain basic and clinical insight into cancer progression. A basic goal of the lab is to understand how complex somatic DNA rearrangements shape the tumor epigenome, and vice versa. More fundamentally, the lab is interested in using structural variation as a lens to study mutational processes that drive somatic evolution, from pre-cancer to metastasis. The lab is committed to translating clinically relevant basic research findings into genomic diagnostics and incorporating these into precision cancer care. This includes the imminent application of clinical cancer whole genome sequencing as the “iPhone” of precision oncology diagnostics.

Visit Lab Website